We used public data in the TCGA and GEO databases and identified the prospective HNSCC tumor antigens for the development of mRNA vaccines, including SREBF1, LUC7L3, LAMA5, PCGF3, HNRNPH1, KLC4, and OFD1, which are associated with NMD factor expression, overall survival prognosis and infiltration of APCs. This evidence concerns the gene SREBF1 and head and neck squamous cell carcinoma.