In the six pancancer immune subtypes (C1-C6) previously reported, HNSCC was mostly clustered into C1 (wound healing) and C2 (IFN-γ dominant) and very little clustered into C3 (inflammatory), C4 (lymphocyte depleted) and C6 (TNF-β dominant) (Thorsson et al., 2018). The gene discussed is LTA; the disease is head and neck squamous cell carcinoma.