To identify potential tumor antigens in HNSCC, the intersection was taken between potential antigen candidate genes differentially expressed in each NMD group and potential antigen candidate genes with overall survival prognosis differences, and then the genes SREBF1, LUC7L3, LAMA5, PCGF3, HNRNPH1, KLC4, and OFD1 were obtained. The gene discussed is OFD1; the disease is head and neck squamous cell carcinoma.