To identify potential tumor antigens in HNSCC, the intersection was taken between potential antigen candidate genes differentially expressed in each NMD group and potential antigen candidate genes with overall survival prognosis differences, and then the genes SREBF1, LUC7L3, LAMA5, PCGF3, HNRNPH1, KLC4, and OFD1 were obtained. This evidence concerns the gene KLC4 and head and neck squamous cell carcinoma.