LMNA and laminopathy: In fact, any mutation in the LMNA sequence aimed at impairing prelamin A processing may either lead to expression of a pathogenetic prelamin A mutant (as in the case of LMNA L647R, which is associated with a progeroid laminopathy (Wang et al., 2016; Wang et al., 2022)) or cause toxic levels of prelamin A (Capanni et al., 2012).