Lipopolysaccharides/Toll-like receptor 4 (LPS/TLR4) signaling mediates HPC development into myofibroblasts that show high levels of IL-6 and TNF-α, potentially promoting upregulation of EGFR and downregulation of PTEN through lncRNA regulation, leading to abnormal Ras and p53 signaling and, ultimately, inducing the malignant transformation of HPCs, potentially leading to HCC development. This evidence concerns the gene PTEN and hepatocellular carcinoma.