Moreover, the oncoprotein GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) can specifically bind to the m5C-modified lncRNA H19, a further indication of the part played by the m5C modification of H19 lncRNA in HCC malignancy (Sun Z. et al., 2020). The gene discussed is H19; the disease is hepatocellular carcinoma.