TGFB1 and hepatocellular carcinoma: To slow the development of HCC, sorafenib boosts SHP-1 activity and inhibits EMT produced by TGF-β (Shih et al., 2001; Dubois et al., 2006; Lopez-Ruiz et al., 2011; Tai et al., 2012; Xu et al., 2014; Fan et al., 2015).