TSLP and neoplasm: Additionally, in response to TSLP, tumor cells have been shown to be secreting IL-1α that act on myeloid cells in the TME, which subsequently secrete TSLP back to tumor cells, creating an IL-1α/TSLP positive feedback loop (Olkhanud et al., 2011; Pedroza-Gonzalez et al., 2011; Kuan and Ziegler, 2018).