It regulates the response of cells to external stimuli through a series of reactions and participates in the growth and development of various tissues and organs (Lee, 2017; Al-Quteimat and Amer, 2020).The overexpression of EGFR was related to the occurrence and development of lung cancer (Russo et al., 2020), breast cancer (Loibl and Gianni, 2017), glioma (Kros et al., 2015) or esophageal cancer (Huang et al., 2016), and EGFR-tyrosine kinase inhibitors are currently the first-line therapeutics for the treatment of advanced non-squamous cell carcinoma with EGFR mutation. Here, EGFR is linked to esophageal cancer.