Moreover, our recent experimental data confirmed that VCAM-1 level is highly elevated in Ang II-infused aorta, which promotes monocyte migration and adhesion to endothelial, the subsequent differentiation of these cells into macrophages and the release of proinflammatory mediators, resulting in hypertension and vascular dysfunction (Yin et al., 2022). Here, AGT is linked to hypertensive disorder.