Our in vivo and in vitro results indicated that blocking VCAM-1 can effectively attenuate Ang II-induced hypertension and cardiac remodeling possibly by reducing VLA-4+ macrophage adhesion/migration and generation of IL-1β, IL6 and TNF-ɑ and ROS, as well as activation of multiple signaling pathway. The gene discussed is TNF; the disease is hypertensive disorder.