Quercetin-treated BCRD rat, serum IFN-γ, IL-10, and IL- 2 levels were significantly upregulated, which probably via promoting anti-tumor immune response. In addition, quercetin partially reversed the pyroptosis on LPS-cultured 4T1 cells in vitro, as evidenced markedly by upregulating the ASC, NLRP3 and Caspase-1. The gene discussed is NLRP3; the disease is neoplasm.