ALOX5 and chronic kidney disease: In addition, PTGS2 (Prostaglandin-Endoperoxide Synthase 2) and ALOX5 (Arachidonate 5-Lipoxygenase) both are proinflammatory enzymes, that catalyze the metabolism of arachidonate to prostaglandins and leukotrienes, involved in the inflammatory reaction of CKD (Li et al., 2018; Beltrán-Noboa et al., 2022).