As shown in Figure 9A, according to degree > 4.8, five components (isopongaflavone, gossypetin, myricetin, quercetin, and liquiritin) and four targets (AKR1B1, PTGS2, CA2, and ALOX5) were key and may play an important role in treating CKD. This evidence concerns the gene PTGS2 and chronic kidney disease.