CD4 and central nervous system cancer: The results revealed that gliomas of SGMRS high-risk group harbored more macrophages (including M0, M1, and M2), resting NK cells, and resting memory CD4+ T cells infiltrated into the tumor microenvironment, and fewer plasma cells and activated NK cells (Figure 8A), depicting distinctive immune cell infiltration models between SGMRS high- and low-risk groups.