In addition to shifting energy metabolism towards fat utilization, SGLT-2 inhibitors were demonstrated to attenuate obesity-related chronic inflammation by reducing M1-polarized macrophage accumulation and inducing the anti-inflammatory M2 macrophage phenotype within adipose tissue and liver in diet-induced obese mice (Xu et al., 2017; Xu et al., 2019). Here, SLC5A2 is linked to obesity due to melanocortin 4 receptor deficiency.