TNF and colitis: Q-PCR analysis showed that DSS-colitis-induced up-regulated mRNA expression of Cgas, Il10, Ifnb1, Tnf, and Il1b was significantly reduced in STING deficient mice (For Cgas: p < 0.01; For Il10: p < 0.01; For Ifnb1: p < 0.001; For Tnf: p < 0.001; For Il1b: p < 0.001) (Figure 7O).