STING1 and multiple sclerosis: Notably, it was recently demonstrated that the type I interferon response in microglia induced by GCV was not mediated through stimulator of interferon genes (STING), attributing to the ability of GCV to reduce neuroinflammation in the cultured microglia and in a mouse model of multiple sclerosis (experimental autoimmune encephalomyelitis, EAE) (Mathur et al., 2017).