Increased oxidative stress provokes the release of pro-inflammatory mediators such as interleukin-8 (IL-8), TNF-α, COX-2 upregulation, and NF-ƙB activation that plays role in inflammatory cascade further aggaravating ulcer (Khan et al., 2011; Sisay et al., 2017). The gene discussed is PTGS2; the disease is ulcer disease.