Antioxidant and nitric oxide free radical scavenging activity has been shown by bergapten, which may be responsible for its effectiveness as anti-ulcer agent and further validated by LPO, catalase, GST, GSH and SOD assay (Mehmood et al., 2015; Sisay et al., 2017; Liang et al., 2021). This evidence concerns the gene SOD1 and ulcer disease.