AIF1 and rheumatoid arthritis: AIF-1 is a cytoplasmic, inflammation-responsive protein and Pawlik and coworkers demonstrated that the patients with the AIF-1 rs2259571 GG genotype have a poorer response (DAS28 > 2.4 at 6 months) to MTX treatment by studying 221 Poland patients with RA (p = 0.03, OR = 2.44) (Pawlik et al., 2013).