Molecular biological mechanism studies have shown that DHE has a regulatory effect on tumor angiogenesis, and can play an anti-CAG effect by inhibiting the relative expression of genes and proteins related to the vascular endothelial growth factor (VEGF) signaling pathway mediated by hypoxia-inducible factor-1 alpha (HIF-1α) (Table 3). Here, HIF1A is linked to neoplasm.