MMP1 and arthritic joint disease: Simultaneously, DHE could inhibit the serum level of pro-inflammatory factors, including TNF-α, interleukin-1 beta (IL-1β), IL-6, and interleukin-17 (IL-17), as well as the relative mRNA expression of matrix metallopeptidase 1 (MMP-1) and matrix metallopeptidase 3 (MMP-3) in MH7A arthritis synovial fibroblasts.