Two core networks were generated by hub gene screening using the MCODE plugin of Cytoscape, and AKT1, CTNNB1, HSP90AA1, ESR1, CCND1, and EGFR were identified as key hub proteins, which may play an important role in the efficacy of icaritin in the treatment of nasopharyngeal carcinoma. The gene discussed is ESR1; the disease is nasopharyngeal carcinoma.