In addition, administering NOX2-inhibitor in LPS-induced ALI mice improved the survival rate of ALI model mice, and drastically reduced the production of pulmonary ROS as well as pulmonary inflammatory factors (such as MCP-1, TNF-α, IL-17A) (Fisher et al., 2019; Nadeem et al., 2019). The gene discussed is TNF; the disease is acute respiratory distress syndrome.