In addition, in animal studies of AP, treatment with emodin increased nuclear translocation of Nrf2, inhibited NLRP3 inflammasome and NFκB inflammatory pathway activation, down-regulated TNF-α, IL-1β, and IL-6 expression, and effectively protected rats from AP-related lung injury (Gao et al., 2020). The gene discussed is NLRP3; the disease is alkaline phosphatase measurement.