SP1 and non-small cell lung carcinoma: Interestingly, qRT-PCR results suggested that SP1 could also attenuate the promoting effect of Curcumol on miR-125b-5p in NSCLC cells (fold change of miR-125b‐5p expression level: in A549 cells pcDNA3.1 group 0.97 ± 0.08; pcDNA3.1-SP1 group 0.32 ± 0.03; pcDNA3.1 + Curcumol group 1.20 ± 0.03; pcDNA3.1-SP1 + Curcumol group 0.64 ± 0.11, in H1975 cells pcDNA3.1 group 0.92 ± 0.09; pcDNA3.1-SP1 group 0.42 ± 0.06; pcDNA3.1 + Curcumol group 1.56 ± 0.13; pcDNA3.1-SP1 + Curcumol group 1.11 ± 0.12) (Figure 4F).