Similar to XBJ, DIS reduced the over-expression of MPO in lung tissues of sepsis mice in flow cytometry and WB assays (Figures 8A–D), whereas, the XBJ + DIS treatment group did not show a remarkable difference compared with the DIS or XBJ treated group, suggesting that XBJ might reduce the NETs formation by inhibiting GSDMD. The gene discussed is MPO; the disease is Sepsis.