Studies have shown that with the increased intake of PUFAs in diet, the level of ferroptosis-related genes such as GPX4, SLC7A11, DHFR and FSP1 in tumor cells has changed, which can promote the lipid peroxidation of cancer cells in the acidic tumor microenvironment, thus induce the ferroptosis in cancer cells (Dierge et al., 2021). Here, DHFR is linked to cancer.