Consistently, the levels of Scr, BUN and the expressions of Kidney injury molecule-1 (Kim-1) and Neutrophil gelatinase-associated lipocalin (Ngal), AKI markers, were markedly elevated in AKI mice, which were significantly aggravated after EP4 inhibitor treatment (Figures 2D,E). Here, HAVCR1 is linked to acute kidney injury.