Previous studies have suggested that IL-8 is an inflammatory cytokine released from many types of cells, such as macrophages, stromal, endothelial, epithelial and tumor cells, involved in promoting EMT, angiogenesis, tumor growth, metastasis and the immunosuppressive microenvironment in human cancers including CRC (105–112). Here, CXCL8 is linked to colorectal carcinoma.