IFNG and neoplasm: For example, studies have shown that IL-12 produced from mature dendritic cells is a strong inducer of the antitumor-specific immune response (64), and IFN-γ, secreted by T helper (TH)-1 cells, cytotoxic T cells and nature killer cells, plays a key role in the activation of anticancer cellular immunity and the induction of tumor cell apoptosis (65).