Previous studies have suggested that IL-8 is an inflammatory cytokine released from many types of cells, such as macrophages, stromal, endothelial, epithelial and tumor cells, involved in promoting EMT, angiogenesis, tumor growth, metastasis and the immunosuppressive microenvironment in human cancers including CRC (105–112). The gene discussed is CXCL8; the disease is neoplasm.