(159) showed that non-small cell lung cancer-derived cell lines treatment with IFN-γ at a low dose induced a higher proportion of CD133 positive CSCs, and treatment with IFN-γ at a high dose resulted in enhanced apoptosis of tumor cells, indicating a modulatory effect of a low dose of IFN-γ on tumor cell stemness. The gene discussed is PROM1; the disease is neoplasm.