Therefore, we decided to utilize mice carrying the specific deletion of Syk in neutrophils [Sykfl/flMrp8-cre+ mice (36, 37),], available in our laboratory, as an experimental model to test whether the specific impairment of this signaling pathway in neutrophils was sufficient to affect their interactions with γδ T cells in IMQ-induced psoriasis. Here, SYK is linked to psoriasis.