To better elucidate the role of neutrophils in psoriasis development, we have utilized the imiquimod (IMQ)-induced mouse model of psoriasis, which consists of the topical administration of Aldara TM cream - containing the Toll-like receptor 7 and 8 (TLR7/8) ligand IMQ (5%) (3, 27). This evidence concerns the gene TLR7 and psoriasis.