Similarly, Wallace et al., showed that a single i.p. injection of 18mg/kg DMXAA led to cytokine release and tumor cell necrosis 24 hours later, and tumor reduction for up to 30 days, followed by relapse in EG7 tumors; activated DCs were seen by 24 hours in DLN followed by a rapid increase in the number of splenic tumor-specific CD8+ T cells (16). The gene discussed is CD8A; the disease is neoplasm.