PDCD1 and renal cell carcinoma: In renal cell carcinoma, the combination of IPI+anti-PD-1 was associated with better response (objective response rate [ORR] 42% versus 27%) and PFS (median PFS, 11.6 versus 8.4 months) compared to sunitinib in patients with intermediate or poor risk renal cell carcinoma (RCC) in the first line setting (41).