A study by Popeda and colleagues comparing transcriptional changes between breast cancer primary tumors and lymph node metastases found that the metastases had an upregulation of ATG10 (autophagy related 10), S100B (S100 calcium-binding protein B), and GATA3 (GATA binding protein 3), whilst a decrease in the expression of 33 genes was found, most of which were associated with innate immunity and the complement cascade (137). This evidence concerns the gene ATG10 and breast cancer.