IFITM3 and cancer: The IFITM1, IFITM2 and IFITM3 proteins influence the epithelial–mesenchymal transition (EMT) status, cell migration, invasion and the presence of distant metastases, as has been shown in both in vitro and in vivo studies performed with various cancer cell lines, animal models and patient samples (15, 16, 64, 71, 151, 154, 155, 164, 166, 167, 177–179).