IFITM3 and neoplasm: Although IFITM overexpression was described in primary tumor tissues compared to adjacent normal tissues, even higher IFITM1 and IFITM3 expression levels were detected in invasive tumor cells and metastatic lymph nodes draining gastric or colon tumor tissue, indicating a connection between IFITMs and tumor invasiveness and progression (71, 154, 157, 164).