Although the expression of CSF1R, PLEK, ITGB2, TYROBP and LAPTM5 and their relationship with M2 macrophages in CRSwNP has not been explored yet, these genes are potential M2 macrophage-related biomarkers involving in the pathogenesis of CRSwNP. Here, ITGB2 is linked to chronic rhinosinusitis with nasal polyps.