Although, loss of gut homeostasis in IBD involves the participation of lamina propria and infiltrating immune cells, such as granulocytes, antigen-presenting cells (APCs), macrophages (Mø), B and T cells (29–31), as well as inflammatory cytokines, such as inflammasome-regulated IL-1β and IL-18, amongst others (TNF-α, IL-6, IL-12, IL-17, IFN-γ, GSDM (32, 33)). The gene discussed is TNF; the disease is inflammatory bowel disease.