SIRT1 and atherosclerosis: Of note, in atherosclerosis, diabetes, and diabetic retinopathy using a SIRT1 agonist, LXR is deacetylated by SIRT1 at a specific conserved lysine (K432 in LXRα and K433 in LXRβ), thereby activating LXR (185–188) suggesting that SIRT1 may be a potential IBD target to promote LXR-mediated cholesterol efflux.