Hence, neonates with high severity score and with clefts affecting the lip and alveolus (BCLP/UCLP) presenting higher levels of GM-CSF, TNF, IL-1ß/-6/-8 on tongue smear samples might therefore be more at risk for progression of inflammatory processes than neonates with low severity score or cleft of the palate only (CPo). The gene discussed is IL1B; the disease is cleft palate.