Indeed, the CD56highCD16+ cells have been described as a phenotypic and functional intermediate between CD56highCD16- and CD56dimCD16+ cells, endowed with cytolytic activity and their accumulation has been also associated with aging (61, 62),Moreover, loss of CD56highCD16- may also reflect their migration to the inflamed lungs accordingly to their high expression of the chemokine receptor CXCR3, CXCR6 and CCR5 and also supported by the increased concentration of the ligands for these chemokine receptors observed in bronchoalveolar lavage of COVID-19 patients (30, 32, 33, 63). This evidence concerns the gene CXCR6 and COVID-19.