TNF and Parkinson disease: In the process of Parkinson’s disease, for example, after the activation of microglia as the main cells of immune function, may cause nerve nutrition through compound, such as brain derived neurotrophic factor, nerve protective effect, but there are also likely to produce neurotoxicity of proinflammatory cytokines (such as tumor necrosis factor (TNF), interleukins) (117, 118).