TLR8 and autoimmune lymphoproliferative syndrome: Many IEIs resulting from mosaicism are also germline disorders, as in the case of most autoinflammatory disorders and ALPS, whereas few IEIs are predominantly caused by somatic mutations (eg, VEXAS syndrome, TLR8 gain-of-function, and Ras-associated autoimmune leukoproliferative disorder) (31–33).