NLRP3 and obesity due to melanocortin 4 receptor deficiency: The activation of ILC3s in the obese mice was mediated by NLR family Pyrin domain-containing (NLRP)3 inflammasome-derived IL-1β in classically activated (M1) macrophages: NLRP3 deletion or treatment with anakinra (IL-1Ra) attenuated obesity-induced asthma.