As shown in Figure 5B, at Day 16, the mean tumor volume in CD4+ TLEX-CD8086 cell immunized mice (703 mm3) was significantly smaller than that in CD4+ TLEX-null cell (1209 mm3), LEX-CD8086 (1146 mm3), LEX-null (1552 mm3) immunized mice, all the mice in the PBS and CD4+ T cells control group died 20 days after the tumor cell challenge. The gene discussed is CD4; the disease is neoplasm.