Conversely, in neutrophils from patients with severe disease, we observed significant activation of NF-kB signaling, and TNF signaling pathways, as well as oxidative stress response pathways (e.g., cyclooxygenase genes, glutathione metabolism, and oxidative phosphorylation), compared to those from mild COVID-19 patients (Figure 2C). The gene discussed is TNF; the disease is COVID-19.