IRAK3 and COVID-19: Remarkably, expression of these genes is attenuated in neutrophils from the severe patients, whose neutrophils displayed increased activation markers including GBP5 (activator of NLRP3 inflammasome assembly) (34), FCER1G (implicated in IL-1b production by neutrophils) (35), and CD177, previously associated with COVID-19 severity and death (36), as well as stress-related genes such as IRAK3, FKBP5, IL1R2 (Figure 2B).