Of note, neutrophils from C5aR2-deficient mice showed a decreased chemotaxis towards C5a, a finding that aligns with the reduced disease activity observed in C5aR2-deficient mice in the passive transfer mouse model of EBA, while in the passive transfer mouse model of BP, C5aR2-deficient mice developed significantly more skin lesions (28, 52). This evidence concerns the gene C5 and acquired epidermolysis bullosa.