Of them, PON1 and CYP2C9 were protective genes for HCC survival with HR<1, and HMMR, SPP1, CCDC134, HTATIP2, BSG, TKT and EFNA3 were risk genes with HR>1 (Figure 4C and Supplementary Table S4). The gene discussed is EFNA3; the disease is hepatocellular carcinoma.