LRBA and hyperinsulinemic hypoglycemia, familial, 4: Identification of a monogenic disorder can have a marked impact on care provided for these patients through the possibility of providing targeted therapies, as we and others have shown before with anakinra for patients with IL10 receptor mutations (7) and abatacept for LPS Responsive Beige-Like Anchor Protein (LRBA) deficiency (8).