To address this, a subsequent study showed that TNFR2-deficient Teffs failed to induce full-fledged colitis in Rag1 KO mice due to their impaired capacity to produce Th1 cytokines, owing to increased p100/p52 ratio and thus defective non-canonical NF-κB signaling (74). The gene discussed is TNFRSF1B; the disease is colitis.