CXCL1 and neoplasm: But, in contrast, some studies have also pointed out that RIPK1 and RIPK3-drived tumor cell necroptosis could induce CXCL1 and SAP130 release that leads to mincle ligation activation and MDSC and M2 macrophage infiltration, which promotes and accelerates immunosuppressive and tumorigenesis, respectively.