But, in contrast, some studies have also pointed out that RIPK1 and RIPK3-drived tumor cell necroptosis could induce CXCL1 and SAP130 release that leads to mincle ligation activation and MDSC and M2 macrophage infiltration, which promotes and accelerates immunosuppressive and tumorigenesis, respectively. Here, SAP130 is linked to neoplasm.