CALR and neoplasm: The expression of CRT on the cell surface presents an “eat-me” signal and is recognized by CD91 and phagocytosed, which promotes DC maturation and activation, leading to the cross-presentation of tumor antigens and tumor-specific cytotoxic T lymphocyte responses, as well as a large-scale release of proinflammatory cytokines such as TNF-α and IL-6.