During the ICD response in tumor cells, eukaryotic initiation factor 2α (eIF2α) is phosphorylated under the influence of specific drugs or external factors, accompanied by the suspension of protein translation, which is a severe stress response of the cellular endoplasmic reticulum, with activation of pro-apoptotic caspase-3 and caspase-8, hydrolysis of endoplasmic reticulum proteins. The gene discussed is EIF2A; the disease is neoplasm.