Except to Lactobacillus, Enterococcus genus were involved in antibiotic resistance and exacerbated the progression of alcoholic liver disease by increasing toll-like receptor 2-mediated sIL-1β secretion on Kupffer cells, while odoribacter genus were also highly associated with NAFLD phenotype in mice induced by high fat diet or high-fructose diet compared to control (61, 62). The gene discussed is TLR2; the disease is metabolic dysfunction-associated steatotic liver disease.