After adjustment for age, sex, race, poverty income ratio, education levels, smoking status, DM, hyperlipidemia, hypertension, ALT, AST, glycohemoglobin, SBP, DBP, TC, TG, high SII levels were an independent risk factor for hepatic steatosis (OR = 1.30, 95% CI: 1.10–1.52, P < 0.01). The gene discussed is GPT; the disease is hyperlipidemia.