After adjustment for age, sex, race, poverty income ratio, education levels, smoking status, DM, hyperlipidemia, hypertension, ALT, AST, glycohemoglobin, SBP, DBP, TC, TG, high SII levels were an independent risk factor for hepatic steatosis (OR = 1.30, 95% CI: 1.10–1.52, P < 0.01). This evidence concerns the gene GPT and Hepatic steatosis.