Furthermore, in adaptive NK cells, coculture with HIV-1BaL infected CD4+ T-cells maintained NKG2C expression at higher levels compared to uninfected cultures, reflected by a lower NKG2A/NKG2C ratio (Two-way ANOVA, p-value = 0.0463 Figure 5B), suggesting HIV infection might be indirectly driving NKG2C expression on NK cells. Here, CD4 is linked to HIV infectious disease.