In general, a low-grade chronic inflammation provoked by the release of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and interferon-γ), chemokines, and soluble factors by the primary tumor cells and cells of the microenvironment into the bloodstream is suggested to stimulate CVD and heart failure (4). This evidence concerns the gene IL1B and heart failure.