TNF and obesity due to melanocortin 4 receptor deficiency: The release of inflammatory mediators from adipose tissue is obesity such as leptin, adiponectin, resistin, visfatin and other important immunological factors such as tumor necrosis factor (TNFα), IL-1, IL-6, plasminogen activator inhibitor type I (PAI-I), CCL2, and different complement factors produce obesity-induced chronic inflammation (50, 69–72).