NLRP3 and atherosclerosis: Subsequent KEGG enrichment analyses revealed that these DEGs were mainly involved in necroptosis, lipid and atherosclerosis, the NOD-like receptor signaling pathway, GnRH signaling pathway, natural killer cell mediated cytotoxicity, the MAPK signaling pathway, apoptosis, and Influenza A. Previous study showed that the upregulated expression of the NOD-like receptor family NLRP3 inflammasome plays a critical role in neuronal necroptosis (32).