Instead, several genes were upregulated in the morphine group, including C-type lectin domain family 7 member A (CLEC7A), a myeloid-predominant pattern-recognition receptor implicated in protection from Alzheimer’s disease (99, 100), type II major histocompatibility genes such as MAMU-DQA1, which are increased in macrophage activation (101), and the intermediate filament protein gene vimentin (VIM), which is increased in macrophages differentiation and activation (102). Here, VIM is linked to early-onset autosomal dominant Alzheimer disease.