ADAM17 is highly expressed or upregulated in cancer (76, 77) and other inflammation-related diseases, including kidney disease (78), sepsis (79), cicatrization (80), diabetic retinopathy (81), myocardial fibrosis (82), aortic dissection (83), arthritis (84) and atherosclerosis (7). The gene discussed is ADAM17; the disease is arthritic joint disease.