In a co-cultured mouse bone marrow-derived macrophages with ADAM17-WT or ADAM17-KO tumor cells, knockdown of ADAM17 significantly diminished the expression of CD163 or CD206, IL-6, IL-10, and CCR7 in bone marrow-derived polarized macrophages, suggesting an important role of ADAM17 in tumorigenic macrophages. Here, IL6 is linked to neoplasm.