Evidence suggests that ADAM17 promotes tumor-associated macrophage polarization and angiotensin II-mediated pro-growth and pro-migration signals by shedding EGFR ligands, including heparin-binding EGF-like growth factor (HB-EGF) and AREG (members of the EGF family), from the cell membrane (17, 32). Here, AREG is linked to neoplasm.