Although opioid receptors and interacting, Gi/o and Regulators of G protein signaling (RGS) proteins, were shown to play key roles in neuronal signaling (Georganta et al., 2013; Papakonstantinou et al., 2015; Pallaki et al., 2017), it is unknown whether κ-OR activation by specific agonists can induce the autophagic machinery in neuroblastoma cells stably expressing the human κ-OR and whether these effects could result in synaptic alterations implicated in stress-related behaviors. The gene discussed is OPRK1; the disease is neuroblastoma.