STXBP1 and amyotrophic lateral sclerosis: Individuals diagnosed with delayed development and amyotrophic lateral sclerosis carry UNC13A (coding for Munc13-1) (Engel et al., 2016; Tan et al., 2020), syntaxin-binding protein (STXBP1, coding for Munc18-1) in individuals with intellectual disorder and epilepsy (Hamdan et al., 2009; Carvill et al., 2014), and dynamin 1 (DMN1) in epilepsy (Appenzeller et al., 2014).