Furthermore, mutations in the secretory carrier-associated membrane protein 5 (SCAMP5), a synaptic vesicle enriched protein responsible for the trafficking and synaptic localization of NHE6, were reported in idiopathic ASD and autism-like neurodevelopmental disorder with the manifestation of epilepsy (Castermans et al., 2010; Hubert et al., 2020). This evidence concerns the gene SLC9A6 and epilepsy.